IndraLab

Statements

OTULIN activates OTULIN. 3 / 3
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"This is in stark contrast to the interaction of HOIP with OTULIN, which was substantially increased by OTULIN overexpression (XREF_FIG C)."
27545878
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"This interaction is negatively regulated by phosphorylation of OTULIN on Y56, thereby disrupting binding to HOIP and abrogating OTULIN-dependent suppression of LUBAC [ 29 , 30 ]."
34074601
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"An increase in the type 1 interferon signature is present in these patients; • otulinopenia [5] : autosomal recessive AID caused by mutations in the FAM105B gene encoding the OTULIN deubiquitinase."
38575108