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Statements

USP18 activates Fibrosis. 2 / 2
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"FOXO3 and USP18 Dynamics in Bleomycin-Induced Mouse Lung Fibrosis."
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"The natural flavonoid cardamonin (CAR), a specific USP18 agonist, significantly improves cardiac function in TAC mice by enhancing USP18-mediated anti-hypertrophic effects, as evidenced by increased ejection fraction (EF%), reduced B-type natriuretic peptide (BNP) levels, and attenuated myocardial inflammation/fibrosis [157]."
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