IndraLab

Statements

USP3 inhibits IFNB1. 4 / 4
| 4
reach
"Cellular ubiquitin specific proteases, USP21, USP3 and USP15, a subfamily of deubiqutinase, remove K63 linked polyubiquitin chains from RIG-I and block it to induce IFN-beta."
28286234
reach
"Ectopic expression of USP3 inhibited IFN-beta promoter activity in cells treated with low molecular weight (LMW) poly (I : C), and in cells infected with VSV."
28295214
reach
"Ectopic expression of USP3 inhibited IFN-beta promoter activity in cells treated with high molecular weight (HMW) poly (I : C), whereas gene silencing of USP3 enhanced IFN-beta protein expression under similar treatment."
28295214
reach
"The ectopic expression of USP3 in HEK293T cells that are treated with low molecular weight poly (I : C) and THP-1 cells infected with VSV attenuated the IFN-beta promoter activity."
33138315