IndraLab

Statements

USP3 inhibits IFNB1. 5 / 5
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"Cellular ubiquitin-specific proteases, USP21 ( Fan et al., 2014 ), USP3 ( Cui et al., 2014 ) and USP15 ( Zhang et al., 2015 ), a subfamily of deubiqutinase ( Reyes-Turcu et al., 2009 ), remove K63-lin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Ectopic expression of USP3 inhibited IFN-beta promoter activity in cells treated with high molecular weight (HMW) poly (I : C), whereas gene silencing of USP3 enhanced IFN-beta protein expression under similar treatment."
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"Ectopic expression of USP3 inhibited IFN-beta promoter activity in cells treated with low molecular weight (LMW) poly (I : C), and in cells infected with VSV."
28295214
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"Cellular ubiquitin specific proteases, USP21, USP3 and USP15, a subfamily of deubiqutinase, remove K63 linked polyubiquitin chains from RIG-I and block it to induce IFN-beta."
28286234
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"The ectopic expression of USP3 in HEK293T cells that are treated with low molecular weight poly (I : C) and THP-1 cells infected with VSV attenuated the IFN-beta promoter activity."
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