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RPS6KB1 phosphorylates RPS6 on S6. 21 / 27
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"In response to various anabolic stimuli, mTOR phosphorylates p70S6 kinase (p70S6K) which in turn phosphorylates the ribosomal protein S6 (rpS6) to positively affect muscle growth ."
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"In response to various anabolic stimuli, mTOR phosphorylates p70S6 kinase (p70S6K) which in turn phosphorylates the ribosomal protein S6 (rpS6) to positively affect muscle growth ."
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"Activation of mTOR by leucine leads to the phosphorylation of ribosomal protein p70 S6 kinase (p70S6K) which, in turn, phosphorylates the ribosomal protein S6 (rpS6) and up-regulates a subclass of mRN[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Additionally, p70S6K can further phosphorylate the ribosomal protein S6 (RPS6) (S236, +81% CFC), and reduction of the levels of p70S6K has been shown to improve the AD-like phenotype of 3xTg-AD mice [62]."
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"In addition, S6K1 has the ability to stimulate ribosomal biosynthesis (Jastrzebski et al., 2007) and can promote the phosphorylation of ribosomal protein S6 (rpS6), an important component of 40S ribosomes (Magnuson et al., 2012; Ruvinsky and Meyuhas, 2006)."
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"Activated mTORC1 phosphorylates S6K1, which phosphorylates S6 (40S ribosomal protein S6), enhancing the translation of mRNAs with a 5 '-terminal oligopolypyrimidine (5 '-TOP)."
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"Upon activation, p70S6K phosphorylates ribosomal protein S6 (RPS6) and other downstream targets involved in protein synthesis and cell growth."
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"Activated RPS6KB1 phosphorylates RPS6 (ribosomal protein S6) and other components involved in the translation machinery, enhancing the translation of mRNAs that encode ribosomal proteins and translation factors [138]."
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"S6K1 phosphorylates ribosomal protein S6 (RPS6) (a component of the 40S ribosomal subunit), leading to active translation of mRNAs involved in ribosome biogenesis [8] ."
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"mTORC1 kinase modulates translation by phosphorylating two substrates, the 4E-BP1 protein and S6K1 kinase, which in turn phosphorylates the ribosomal protein S6 (rpS6)."
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"mTORC1 controls mRNA translation via at least two well-established downstream targets: p70S6 kinase (p70S6K), which phosphorylates several translation factors including the ribosomal protein S6 (pS6), and repressor proteins of eukaryotic initiation factor 4E (eIF4E) termed 4E-BPs [5]."
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"mTORC1 controls mRNA translation via at least two well-established downstream targets: p70S6 kinase (p70S6K), which phosphorylates several translation factors including the ribosomal protein S6 (pS6), and repressor proteins of eukaryotic initiation factor 4E (eIF4E) termed 4E-BPs [5]."
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"At a downstream level, mTORC1 activates p70 ribosomal protein S6 kinase1 (p70S6K), which further phosphorylates ribosomal protein S6 (RPS6) and carbamoyl phosphate synthetase 2-aspartate transcarbamoylase-dihydroorotase (CAD), responsible for inducing ribosome biogenesis and de novo pyrimidine biosynthesis, respectively [58]."
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"The p-S6 antibody we used recognizes p-S6(ser235/236), which can be phosphorylated either by the ERK-activated RSK kinase or by the TORC1-activated S6 kinase (S6K1)."
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"S6K1 also phosphorylates ribosomal protein S6 (rpS6; Ser235/236 and Ser240/244) [95,96,97], a protein within the small (40S) ribosomal subunit."
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"Subsequently, activated p70S6K phosphorylates S6 (40S ribosomal protein S6) and other ribosomal proteins and elongation factors and therefore enhances the translation of mRNAs and promotes proteins synthesis XREF_BIBR."
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"Activated mTOR and ERK phosphorylate p70S6 kinase (p70S6K), which, in turn, phosphorylates the ribosomal protein S6 (RP-S6) and the eukaryotic translation initiation factor 4E (eIF4E) binding protein [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Activated mTOR and ERK phosphorylate p70S6 kinase (p70S6K), which, in turn, phosphorylates the ribosomal protein S6 (RP-S6) and the eukaryotic translation initiation factor 4E (eIF4E) binding protein [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, activation of mTOR promotes phosphorylation of p70 ribosomal protein S6 kinase (p70S6K), which subsequently phosphorylates the ribosomal protein S6 (rpS6) and enhances HIF-1α translation [126]."
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"Whereas mTORC1 mediates cell growth and organ size through S6K1-dependent phosphorylation of ribosomal protein S6 (rpS6), mTORC1-dependent 4E-BP1 phosphorylation mediates cell proliferation."
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"Once phosphorylated, S6K1 regulates protein translation in part by phosphorylating and activating ribosomal protein S6 (rpS6)."
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