IndraLab

Statements

RPS6KB1 phosphorylates RPS6 on S6. 5 / 5
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"Activated mTORC1 phosphorylates S6K1, which phosphorylates S6 (40S ribosomal protein S6), enhancing the translation of mRNAs with a 5 '-terminal oligopolypyrimidine (5 '-TOP)."
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"The IFNgamma activated p70 S6 kinase subsequently phosphorylates the 40S S6 ribosomal protein on serines 235/236, to regulate IFNgamma dependent mRNA translation."
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"mTORC1 controls mRNA translation via at least two well-established downstream targets: p70S6 kinase (p70S6K), which phosphorylates several translation factors including the ribosomal protein S6 (pS6), and repressor proteins of eukaryotic initiation factor 4E (eIF4E) termed 4E-BPs [5]."
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"mTORC1 controls mRNA translation via at least two well-established downstream targets: p70S6 kinase (p70S6K), which phosphorylates several translation factors including the ribosomal protein S6 (pS6), and repressor proteins of eukaryotic initiation factor 4E (eIF4E) termed 4E-BPs [5]."
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"Subsequently, activated p70S6K phosphorylates S6 (40S ribosomal protein S6) and other ribosomal proteins and elongation factors and therefore enhances the translation of mRNAs and promotes proteins synthesis XREF_BIBR."
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