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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

ZUP1 inhibits reactive oxygen species. 2 / 2

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"In fibroblasts derived from Leber Hereditary Optic Neuropathy ( LHON ) harboring the m.11778G > A mutation , DUb highly decreases reactive oxygen species ( ROS ) from affected and control cells [ 102 ] ."

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"Furthermore , DUB inhibition did not increase ROS levels , nor elicit a strong NRF2-mediated antioxidant response ( based on expression of two canonical target genes NQO1 and GCLC ) ( Figures 4B , 4C and S4B ) ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...