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ZUP1 inhibits reactive oxygen species. 2 / 2

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"In fibroblasts derived from Leber Hereditary Optic Neuropathy ( LHON ) harboring the m.11778G > A mutation , DUb highly decreases reactive oxygen species ( ROS ) from affected and control cells [ 102 ] ."

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eidos

"Furthermore , DUB inhibition did not increase ROS levels , nor elicit a strong NRF2-mediated antioxidant response ( based on expression of two canonical target genes NQO1 and GCLC ) ( Figures 4B , 4C and S4B ) ."

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ZUP1 inhibits reactive oxygen species. 2 / 2

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