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CTNNB1 leads to the deubiquitination of CTNNB1. 13 / 13
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"In the absence of Wnt ligands stimulation, adenomatous polyposis coli (APC), Axin, casein kinase 1α (CK1α), and GSK3 form the β-catenin destruction complex, which induces the phosphorylation and subse[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the mammalian WNT signaling pathway, for example, phosphorylation of beta-catenin by PKA is known to inhibit the ubiquitination of beta-catenin promoted by CKI and glycogen Synthetase kinase 3 beta (GSK-3 beta) phosphorylation [XREF_BIBR, XREF_BIBR]."
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"First, unlabeled β-catenin peptides were able to inhibit the ubiquitination of P–β-catenin–Ub (Fig. 9B), P–β-catenin–Ub (Fig. 9C), or P–β-catenin–Ub (Fig. 9D), suggesting their ability to displace the ubiquitinated substrates for binding with the E3."
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"In part, upregulated beta-catenin signals may be mediated by increased phosphorylation of Ser552 and decreased beta-catenin ubiquitination."
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"These results indicate that RIP1 directly interacts with β-catenin, and that the WNT3A-mediated upregulation of RIP1 might increase the stability of β-catenin via direct binding.We found that RIP1 inhibited the ubiquitination of β-catenin to decrease its proteasomal degradation (Fig. 3C)."
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"It was observed that the overexpression of miR-1 led to an increase in β-catenin ubiquitination levels, while the reintroduction of FAM83A reduced β-catenin ubiquitination and stabilized the protein level of β-catenin (Fig. 4E)."
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"Wnt signaling disassembles the beta-catenin destruction complex, which prevents the phosphorylation and subsequent ubiquitination of beta-catenin, thus diverting beta-catenin from the proteasome machinery."
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"In the canonical Wnt pathway, Wnt binds to the Fzd receptors, activates Dishevelled (Dvl) and disassembles the beta-catenin '' destruction complex, " which prevents the phosphorylation and subsequent [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Protein kinase glycogen synthase kinase 3β (GSK3β) is not only a downstream of the PI3K/AKT pathway [49], and GSK3β is also a part of the multicomponent complex in the WNT/CTNNB1 pathway, which phosphorylates and subsequently promotes the ubiquitination and degradation of CTNNB1 [50]."
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"Some cancer related mutations in beta-catenin prevent phosphorylation dependent ubiquitination of beta-catenin, leading to accumulation of beta-catenin in the nucleus."
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"52 Additionally, TRIM50 and TRIM58 have the ability to bind with β-catenin, resulting the breakdown of β-catenin.70,72 Further experiments confirmed that TRIM50 induce β-catenin degradation through protease-ubiquitin system and TRIM58 could significantly induce ubiquitination of β-catenin."
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"In turn, GSK-3β by phosphorylating the Tau protein, exacerbated neurodegeneration.Parkin, an E3 ubiquitin ligase which genetic alterations have been involved in PD development , was shown to protect D[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP8 stabilized beta-catenin protein via inhibiting K48-specific poly-ubiquitination process on beta-catenin protein."
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