IndraLab

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CTNNB1 leads to the deubiquitination of CTNNB1. 7 / 7
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"In the canonical Wnt pathway, Wnt binds to the Fzd receptors, activates Dishevelled (Dvl) and disassembles the beta-catenin '' destruction complex, " which prevents the phosphorylation and subsequent [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Wnt signaling disassembles the beta-catenin destruction complex, which prevents the phosphorylation and subsequent ubiquitination of beta-catenin, thus diverting beta-catenin from the proteasome machinery."
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"Some cancer related mutations in beta-catenin prevent phosphorylation dependent ubiquitination of beta-catenin, leading to accumulation of beta-catenin in the nucleus."
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"Protein kinase glycogen synthase kinase 3β (GSK3β) is not only a downstream of the PI3K/AKT pathway [49], and GSK3β is also a part of the multicomponent complex in the WNT/CTNNB1 pathway, which phosphorylates and subsequently promotes the ubiquitination and degradation of CTNNB1 [50]."
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"In the mammalian WNT signaling pathway, for example, phosphorylation of beta-catenin by PKA is known to inhibit the ubiquitination of beta-catenin promoted by CKI and glycogen Synthetase kinase 3 beta (GSK-3 beta) phosphorylation [XREF_BIBR, XREF_BIBR]."
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"USP8 stabilized β-catenin protein via inhibiting K48-specific poly-ubiquitination process on β-catenin protein."
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"In part, upregulated beta-catenin signals may be mediated by increased phosphorylation of Ser552 and decreased beta-catenin ubiquitination."
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