IndraLab

Statements

INS phosphorylates KCNA3. 6 / 6
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"This would be congruent with our previous findings that insulin-induced phosphorylation of Kv1.3 (Fadool et al., xref , xref ; Marks et al., xref ) and resultant decrease in channel open probability (Fadool et al., xref ) evokes a reduction in anxiety behaviors when intranasally administered to the OB (Marks et al., xref )."
29615878
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"We have previously reported that Kv1.3 channel modulation can be perturbed by adaptor proteins via disruption of src- or insulin-induced Kv1.3 phosphorylation [ xref , xref ]."
19166614
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"Insulin-induced Kv1.3 phosphorylation in the OB (Fadool and Levitan, xref ; Fadool et al., xref ) was lost in DIO mice (Marks et al., xref ) and slices from these mice exhibited loss of insulin modulation of mitral cell excitability, exemplifying a degree of insulin resistance for mitral cell function in the obese state (Fadool et al., xref )."
27242550
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"Most interestingly, the increase in insulin-induced Kv1.3 phosphorylation via IND was significantly less in the OBs from mice raised on the MHF-diet compared to that from mice maintained on control diets ( xref ) (Student’s t -test, α ≤ 0.05)."
19458242
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"Insulin and the incretin hormone, GLP-1, can phosphorylate Kv1.3 at the plasma membrane, decrease Kv1.3 current and upregulate GLUT4 translocation to the membrane to facilitate glucose metabolism."
27242550
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"Using intranasal insulin delivery across the cribiform plate, into the olfactory bulb, we demonstrated that animals maintained on a MHF-diet now failed to exhibit an increase in insulin-induced Kv1.3 phosphorylation, developing a degree of insulin resistance at the level of the ion channel ( xref ) ( xref )."
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