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CGAS inhibits USP18. 2 / 2
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"Besides, we found that overexpression of USP18 again raised cGAS protein levels, and STING, TBK1, IRF3 and p65 phosphorylation levels in PR8-infected A549 cells, whereas these were reduced by interfer[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, interference with cGAS inhibited USP18-mediated IAV replication ( Fig. 5 D), IL-6, TNF-α, IFN-β and CXCL10 synthesis ( Fig. 5 E), and apoptosis ( Fig. 5 F) in IAV-infected A549 cells."
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