IndraLab

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USP15 deubiquitinates SMAD3. 3 / 3
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"USP15 and USP7 were found to resist the mono-ubiquitination of Smad3, enhancing the TGF-β/Smads signal but not regulating the protein level of Smad3 [ 65 ]."

"Multiple mono-ubiquitination of <span class="match term1">SMAD3</span> can be removed by <span class="match term0">USP15</span> and mono-ubiquitination of SMAD4 seems to be removed by FAM/USP9X"

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"Smad3 mono-ubiquitination can be reversed by USP15 [116] ."