IndraLab

Statements

Bortezomib inhibits RELA. 22 / 28
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"Bortezomib indeed decreases nuclear retention of p65 preferentially in PARP inhibitor resistant lines compared to parental UWB1.289 or HCC1937 cells, suggesting that it seems to inhibit NF-kappaB signaling in the setting of acquired PARP resistance."
25686825
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"Bortezomib degraded both cytoplasmic and nuclear pools of p65."
| PMC
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"We found that Bortezomib degrades p65 and IkappaBalpha through different mechanisms."
| PMC
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"Bortezomib treatment in steatotic liver donor reduces NF-kappaB p65 activation and inflammatory I/R injury, improving transplant outcomes of steatotic grafts in a rat model [XREF_BIBR]."
26325610
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"While bortezomib inhibited proteasome, NF-kappaB p65 subunit, and prosurvival genes, 18 clinical activity of bortezomib plus reirradiation was limited."
21750205
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"As shown in XREF_FIG, bortezomib reduces the level of nuclear p65 protein in U266 myeloma cells."
24067362
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"*Targeting the RBM39-MEK5 axis increases the cytotoxicity of bortezomib by inhibiting p65 to synergistically inhibit MM growth."
40048740
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"In our study, Bortezomib degraded not only IkappaBalpha protein but also the p65 subunit of NF-kappaB."
| PMC
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"Similarly, siRNA experiments that inhibit p65 expression and mimic Bortezomib induced degradation of p65 proteins, confirmed that absence or inhibition of p65 does not lead to apoptosis, as represented by the absence of PARP cleavage (XREF_FIG, left panel), nor to induced cell death (XREF_FIG, right panel)."
| PMC
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"Moreover, we found that Bortezomib degraded p65 in leukemia cells."
| PMC
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"Why Bortezomib degrades p65 is not clear."
| PMC
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"Furthermore, inhibition of pan-caspases abolished Bortezomib induced degradation of p65, p105 and Sp proteins, but not that of IkappaBalpha."
| PMC
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"In contrast, p65 mRNA expression was unaffected or even increased in MOLT4 cells, implying that bortezomib perturbs the stability of p65 via NICD downregulation as suggested previously."
24301524
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"After 3 or 7 days of treatment, Disease Activity Index (DAI) as well as histological scores and NF-kappaB p65 protein expression were significantly reduced in mice treated with bortezomib at a dose of 0.6 or 1 mg/kg/day."
28487944
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"The cytoplasmic to nuclear translocation and activation of NF-kappaB is a proteosome-dependant process, and bortezomib has been shown to inhibit nuclear activation of the RelA and NF-kappaB1 subunits in HNSCC [XREF_BIBR]."
21299897
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"While bortezomib inhibited NFκB p65 and BCL-xL 40% in RPMI 8226 MM cells cultured alone, MM cells co-cultured with overweight or obese adipocytes and treated with bortezomib displayed no reduction in these survival factors.Caspases are a family of proteases that can mediate the anti-drug effects of bortezomib and lenalidomide in MM."
37686623
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"Bortezomib also inhibits RELA (NF-kB subunit) and hence inactivates glutaminase.Drug mechanisms are more complex and suggesting them as therapeutic targets directly is not suggestible for treating AD."
37210557
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"Bortezomib also induced degradation of p65 in a dose dependent manner (XREF_FIG), starting at 10-15 nM, and a time dependent manner, starting after 12 h (XREF_FIG)."
| PMC
eidos
"Bortezomib prevents protein degradation , including RelA via the intracellular NF-kB pathway ."
34719869
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"Thus, the RBM39-MEK5 axis upregulates p65, RSK1, and c-Myc in MM cells to promote their proliferation and survival.Aberrant activation of p65 is involved in the malignant growth of MM.36 Bortezomib (Btz), which inhibits p65 activation,37 is the first-line drug used in the clinical treatment of MM."
40048740
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"Western blotting showed that Bortezomib induced degradation of Sp3 and p65 in both cytoplasm and nucleus."
| PMC
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"They showed that proteasome inhibitor bortezomib more effectively inhibited nuclear localization of RELA and p50 than cREL or alternate pathway subunits NF-kappaB2 or RELB in tumor specimens and lines from patients with HNSCC."
18694378