IndraLab

Statements


HSP90 binds HSPA and KCNH2. 4 / 4
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sparser
"Both HSP70 and HSP90 directly interact with hERG (the human ether-á-go-go-related gene) whose disorders can lead to long-QT syndrome and sudden cardiac death [ xref ]."

sparser
"Both HSP70 and HSP90 directly interact with hERG (the human ether-á-go-go-related gene) whose disorders can lead to long-QT syndrome and sudden cardiac death [89]."

sparser
"Mutations such as R752W and G601S strengthen the interaction of hERG with Hsp70 and Hsp90."

sparser
"It could be that hypoxia inhibits Hsp90 binding to hERG by reducing steady state expression levels of endogenous Hsp90 and/or Hsp70."