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USP22 activates SOX2. 2 / 3

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"Our data revealed that knockdown of USP22 decreased the expression of stemness related genes Sox2 and CD133, redox related genes Nrf2 and Sirt1, and quiescence related genes PP2A and c-Myc in GSCs und[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"As presented in Fig. 2 A–B , knockdown of USP22 inhibited the expression of stemness related genes Sox2 and CD133, redox related genes Nrf2 and Sirt1, and quiescence related genes PP2A and c-Myc."

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USP22 activates SOX2. 2 / 3

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