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USP38 increases the amount of MYC. 7 / 7
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"These data suggest that USP38 can enhance c-Myc levels, through a DUB-independent mechanism.To further verify the impact of USP38 on c-Myc, endogenous USP38 was knocked down in the A549 cells with two[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, these data strongly indicate that USP38 is a novel positive regulator of c-Myc.To determine the mechanism by which USP38 increases c-Myc protein levels, USP38 was co-expressed with c-M[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We found that USP38 no longer increased the levels of c-Myc in the presence of the proteasome inhibitor MG132 ( Fig. 2 A), suggesting that USP38 prevents proteasomal degradation of c-Myc."
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"As expected, knockdown of USP38 failed to reduce the c-Myc levels once the cells were treated with MG132 ( Fig. 2 B)."
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"Together, these data imply that USP38 enhances c-Myc levels by inhibiting polyubiquitination and degradation of c-Myc.Given that USP38 can inhibit the degradation of c-Myc, we next determined the effe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As was expected, ectopic expression of USP38 indeed promoted the expression of c-Myc target genes, such as HK2, PKM2, and LDHA ( Fig. 1 E and F)."
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"Besides, When USP38 was co-transfected with c-Myc in HEK293 T cells, the levels of c-Myc were increased by USP38 in a dose-dependent manner ( Fig. 1 B, lanes 1–3)."
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