IndraLab

Statements

signor
No evidence text available
Other
reach
"Moreover, GM-DCs in which TBK1 and IKKepsilon were inhibited by BX795 showed substantial impairment in the phosphorylation of Akt at Ser473 and Thr308 and of PRAS40 and the ribosomal protein S6, and this was more profound than the inhibition observed after inhibition of PI (3) K or mTOR (XREF_FIG and XREF_SUPPLEMENTARY)."
24562310
reach
"BX795 [originally developed as a 3phosphoinositidedependent protein kinase 1 (PDK1)] [90] and a series of azabenzimidazole derivatives [91] inhibit both IKKe and TBK1 at low nanomolar concentrations [92] ."
23395611
reach
"Interestingly BX795, a molecule which inhibits TBK1 and IKKepsilon, has recently been shown to inhibit IFN-I production and signaling in human PBMCs with a mutation induced interferonopathy [8]."
29673738
tas
No evidence text available