IndraLab

Statements

reach
"These signals likely contribute to the ER retention and subsequent degradation of rescuable, trafficking-deficient hERG channels."
39193219
reach
"Deletion of this region (HERG Δ860–899 ) results in the ER retention of HERG channels, but the tetrameric assembly is not disrupted in the HERG Δ860–899 mutant."
15572053
reach
"For example, it is known that transcription levels of Kv1.5 are modulated by glucocorticoids, that Kv3.4 expression is upregulated by skeletal muscle innervation, and that PKA phosphorylation at the surface of the ER augments hERG biosynthesis."
22754540