IndraLab

Statements

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"NLRP3 is also negatively regulated by NO mediated S nitrosylation."
26620909
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"In addition, T cell derived IFNgamma has been shown to downregulate the activity of NLRP3 via activation of inducible nitric oxide synthase (iNOS) in a mouse model of tuberculosis 71; nitric oxide (NO) induces NLRP3 nitrosylation and thereby inhibits NLRP3 activity."
23702978
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"For instance, NO impairs the activity of the NLRP3 inflammasome, a process that is crucial for the control of tissue damage in mice models for Mycobacterium infection and septic shock [79,97]."
26440786
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"In addition, we also observed increased NO production in Txnip -/- cells, which suppressed NLRP3 inflammasome activation, indicating a critical role for TXNIP in the activation of the NLRP3 inflammasome during endotoxic shock."
24098117
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"Cutting edge : nitric oxide inhibits the NLRP3 inflammasome."
23100513
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"The dramatic enhancement of both NO and the expression of iNOS in Txnip -/- macrophages suggested that TXNIP may be involved in NO mediated NLRP3 inhibition."
24098117
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"5 Interestingly, interferon (IFN) and the nitric oxide synthase-2-mediated NO pathways were shown to inhibit NLRP3 activation and thereby prevent tuberculosis associated pathology."
33614031
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"Nitric oxide (NO) has been reported to negatively regulate NLRP3 inflammasome mediated caspase-1 activation [XREF_BIBR]."
26491223
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"Contrastingly, nitric oxide suppresses NLRP3 inflammasome dependent processing of IL-1beta and controls the immunopathology of tuberculosis infection [XREF_BIBR]."
27366746
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"Similarly, the addition of NO donor compounds to macrophages or induction of NO by IFN-gamma treatment inhibited NLRP3 activation."
24062750
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"However, little is known about the regulatory mechanism for NO mediated NLRP3 inflammasome inhibition and the potential role for TXNIP in this progression."
24098117
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"Similarly, a previous study has found that NO inhibits NLRP3 activation, thereby preventing pyroptosis in endothelial cells (Jiang et al., 2020)."
36187801
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"Also study by Mao et al. demonstrated that NO prevented the activation of the NLRP3 inflammasome."
28791024
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"It is interesting to note that NO mediated thiol nitrosylation inhibited assembly and activation of the NLRP3 but not AIM2 inflammasome."
29230217
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"IL-1beta levels are regulated by IFN-gamma-induced nitric oxide inhibition of the NLRP3 inflammasome [XREF_BIBR]."
23790398
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"Both IFN-gamma-induced NO production and NO donor (SNAP) treatment inhibit canonical and Mycobacterium tuberculosis mediated NLRP3 inflammasome activation through induction of NO induced S nitrosylation of NLRP3."
29868015
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"Firstly, the ability of IFN-gamma or NO to specifically inhibit the NLRP3 inflammasome and not other caspase-1 containing complexes indicates that caspase-1 is unlikely to be a functional nitrosylation target in this context."
23160153
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"Our observation that the human NLRP3 inflammasome is inhibited by NO further suggests a potential therapeutic application of NO in the treatment of inflammatory diseases."
23318584
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"Endogenous NO downregulates NLRP3 inflammasome activation and stabilizes mitochondria."
32973739
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"NO inhibits the assembly of the NLRP3 inflammasome."
23160153
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"The addition of an NO donor (SNAP) inhibited the NLRP3 dependent maturation of IL-1beta in these transfected cells, but had no effect on the AIM2 inflammasome, implying that this compound might directly modulate the assembly or activity of the NLRP3 inflammasome (XREF_FIG)."
23160153
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"While Mishra et al. report NO induced nitrosylation of NLRP3 blocks activation by preventing assembly of the inflammasome, the study by Mao et al. suggests that NO downregulates NLRP3 activation through enhancing the removal of the dysfunctional mitochondria that activate NLRP3."
24840700
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"Interestingly, another small molecule, nitric oxide (NO), attenuates NLRP3 inflammasome activity at the post-translational level by direct Snitrosylation 158 ."
32550001
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"In this context, nitric oxide, which is generated in increased amounts by OA chondrocytes in situ, suppresses NLRP3 activation."
25266449
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"Recent studies suggest that nitric oxide (NO), Ca 2+ and cyclic AMP negatively regulate the NLRP3 inflammasome but the detailed mechanisms are unclear XREF_BIBR, XREF_BIBR."
27439607
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"Since NO is an inhibitor of caspase-1 [XREF_BIBR], availability of NO may inhibit NLRP3 inflammasome activation and subsequent IL-1beta and IL-18 production."
32454788
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"In this study, we found that NO not only inhibits NLRP3 inflammasome mediated IL-1beta secretion and caspase-1 activation, but also inhibits NLRC4- and AIM-2-mediated IL-1beta secretion and caspase-1 activation (XREF_SUPPLEMENTARY), but to a much less extent (3-fold decrease for NLRC4 and AIM-2, 40-fold decrease for NLRP3)."
23318584
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"NO thus specifically inhibits NLRP3 inflammasome activation but not the TLR and NF-kappaB signaling pathways."
23318584
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"Interestingly, nitric oxide seems to stabilize mitochondria against dysfunction and suppress NLRP3 activation by S nitrosylation."
25879282
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"Furthermore, S-nitroso-N-acetylpenicillamine (SNAP), an NO donor, markedly inhibited NLRP3 inflammasome activation, whereas the AIM2 and NLRC4 inflammasomes were only partially inhibited by SNAP."
23100513
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"120 showed that a similar NO dependent mechanism suppresses NLRP3 activation during LPS challenge to protect against septic shock."
33614031
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"On the contrary, it is known that NLRP3 inflammasome activity is inhibited by type-1 interferon and nitric oxide [XREF_BIBR]."
32331389
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"Nitric oxide inhibits human NLRP3 inflammasome activation."
23318584
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"These observations establish a mechanism whereby IFN-gamma-induced NO inhibits NLRP3 dependent IL-1 responses."
23160153
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"Overall, these results suggest that excessive NO produced by Txnip -/- cells could inhibit NLRP3 inflammasome activation."
24098117
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"In keeping with this hypothesis, nitrogen oxide (NO) has been reported to induce NLRP3 and caspase-1 nitrosylation and thereby inhibit NLRP3 inflammasome activity (Kim et al., 1998; Mishra et al., 2013)."
32096759
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"We found that NO negatively regulated the activation of the NLRP3 inflammasome by stabilizing mitochondria in macrophages and prevented LPS induced septic shock in vivo."
23318584
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"Additionally, nitric oxide (NO) downregulates NLRP3 activation through enhancing the removal of the dysfunctional mitochondria and preventing assembly of the inflammasome [XREF_BIBR, XREF_BIBR]."
27652274
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"Additionally, nitric oxide (NO) downregulates NLRP3 activation through enhancing the removal of the dysfunctional mitochondria and preventing assembly of the inflammasome [XREF_BIBR, XREF_BIBR]."
27652274
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"Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS induced septic shock."
23318584
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"Interestingly, another small molecule, nitric oxide (NO), attenuates NLRP3 inflammasome activity at the post-translational level by direct S-nitrosylation158.In addition to post-translational and post-transcriptional regulation, a number of molecules can directly or indirectly interact with different components of the NLRP3 inflammasome, through which they impede the assembly of NLRP3 with ASC and caspase-1."
32550001
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"NO inhibits NLRP3 dependent IL-1 responses."
30915076
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"In addition, T cell derived IFNgamma has been shown to downregulate the activity of NLRP3 via activation of inducible nitric oxide synthase (iNOS) in a mouse model of tuberculosis 71; nitric oxide (NO) induces NLRP3 nitrosylation and thereby inhibits NLRP3 activity."
23702978
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"Interestingly, another small molecule, nitric oxide (NO), attenuates NLRP3 inflammasome activity at the post-translational level by direct S-nitrosylation158.In addition to post-translational and post-transcriptional regulation, a number of molecules can directly or indirectly interact with different components of the NLRP3 inflammasome, through which they impede the assembly of NLRP3 with ASC and caspase-1."
32550001
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"Nitric oxide (NO) negatively regulates NLRP3 inflammasome activation through S nitrosylation of NLRP3."
29868015
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"The findings suggest that intravenous Arg supplementation immediately after sepsis restores plasma Arg levels and is beneficial for attenuating septic AKI, partly via NO mediated NLRP3 inflammasome inhibition."
32454788
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"Furthermore, NO suppresses NLRP3 inflammasome activation, which is a multi protein complex that triggers the maturation of the pro inflammatory cytokines IL-1beta and IL-18."
28603491
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"Also, NO inhibits the NLRP3 inflammasome activation in macrophages, which may involve S nitrosylation of NLRP3 and caspase-1 77."
31700106
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"It has been demonstrated that NO negatively regulated the activation of the NLRP3 inflammasome by stabilizing mitochondria in macrophages and prevented lipopolysaccharide induced septic shock [XREF_BIBR]."
26334271
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"In this study, we find that NO donor not only inhibits NLRP3 inflammasome activation in mouse macrophages, but also suppresses human NLRP3 inflammasome activation in human THP-1 cells and primary PBMCs."
23318584
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"Recent studies suggest that nitric oxide (NO), Ca 2+ and cyclic AMP negatively regulate the NLRP3 inflammasome but the detailed mechanisms are unclear XREF_BIBR, XREF_BIBR."
27439607
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"Furthermore, our in vivo results support the hypothesis that excessive NO induced by LPS treatment in Txnip -/- mice inhibited NLRP3 inflammasome activation and then prevented the secretion of IL-1beta."
24098117
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"Interestingly, another small molecule, nitric oxide (NO), attenuates NLRP3 inflammasome activity at the post-translational level by direct Snitrosylation 158 ."
32550001
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"Using an iNOS inhibitor, iNOS specific siRNA and iNOS deficient macrophages, we found that the endogenous NO derived from iNOS negatively regulates NLRP3 inflammasome activation at the late stage of LPS priming."
23318584
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"Since Arg plus L-NIL administration also attenuated kidney injury after CLP, the favorable effect of Arg resulting from NO mediated NLRP3 inflammasome inhibition may be partly responsible for attenuating septic AKI."
32454788
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"Yet, NO has been previously shown to inhibit NLRP3 inflammasome activation through the S nitrosylation of NLRP3 and caspase-1 XREF_BIBR, XREF_BIBR."
28463821
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"These results collectively confirm that the endogenous NO produced by iNOS negatively regulates NLRP3 inflammasome activation in macrophages."
23318584
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"Nitric oxide (NO) has been reported to negatively regulate NLRP3 inflammasome mediated caspase-1 activation [XREF_BIBR]."
26491223
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"It has been reported that NO prevents NLRP3 activation and protects against LPS induced septic shock."
29951054
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"Thus, in both macrophages and transfected 293T cells NO specifically inhibited the assembly and activity of the NLRP3 inflammasome complex."
23160153
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"It was demonstrated that NO suppresses NALP3 inflammasome activation by nitrosylation of NALP3 proteins resulting in decreased synthesis of mature IL-1 beta and IL-18, impaired Th1 immunity and NK cell activation XREF_BIBR."
23936574
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"5 Interestingly, interferon (IFN) and the nitric oxide synthase-2-mediated NO pathways were shown to inhibit NLRP3 activation and thereby prevent tuberculosis associated pathology."
33614031
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"Nitric oxide (NO) negatively regulates NLRP3 inflammasome activation through S nitrosylation of NLRP3."
29868015
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"The findings reported above suggested that exogenous NO donors inhibited NLRP3 inflammasome mediated IL-1beta secretion and caspase-1 activation."
23318584