IndraLab

Statements

USP28 inhibits BRAF. 7 / 7
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"The loss of USP28 promoted MAPK activation and resistance to RAF inhibitor therapy by stabilizing BRAF in cell culture and in vivo models."
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"Both knockdown of USP28 and FBW7 significantly enhanced endogenous BRAF stability (XREF_FIG)."
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"Loss of USP28 enhances BRAF stabilization and confers resistance to vemurafenib in melanoma."
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"Loss of USP28 mediated BRAF degradation drives resistance to RAF cancer therapies."
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"Having established that USP28 and FBW7 reduces BRAF stability, we tested the effect of USP28 and FBW7 depletion on BRAF expression."
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"Importantly, of the 59 patients harboring BRAF V600E mutations 27% (16/59) displayed a> 50% decrease in USP28 mRNA expression levels, suggesting that in tumors harboring BRAF alterations, loss of USP28 may further increase the tumorigenic potential of these tumors by stabilizing BRAF and enhancing downstream MAPK activation."
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"However, we noted that loss of USP28 or FBW7 did not fully prevent BRAF degradation suggesting that BRAF degradation may occur through mechanisms independent of the USP28 and FBW7 axis."
29880484