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Quercetin inhibits CASP1. 19 / 21
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"To determine if CYT or quercetin inhibits caspase-1 activation induced by LPS, cells were exposed to LPS in the presence or absence of CYT (1 mg/ml) or quercetin (0.1 mM)."
21108840
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"They found that quercetin treatment dramatically suppressed the upregulation of NLRP3, C-terminal caspase recruitment domain, and pro-caspase-1 in the knee joints after MSU injection."
35959909
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"Simultaneously, the treatment of quercetin at 50 and 100 mg/kg, as well as allopurinol at 5 mg/kg, remarkably reduced maturation of caspase-1 (quercetin and allopurinol : P <.001) and IL-1beta (querce[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24491314
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"These results suggest that quercetin reduces ExoS and further affects the NLRP3, NLRC4 and caspase-1 pathways."
36788468
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"Quercetin inhibits the NLRC4 inflammasome and caspase-1 induced by P. aeruginosa according to a western blot analysis."
36788468
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"Western blot analysis indicates that LPS treatment induced degradation of caspase-1 precursor, which was inhibited by treatment CYT or quercetin."
21108840
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"Employing Aβ folding reporter SH-SY5Y cells, we showed that quercetin and apigenin reduced Aβ-aggregation, oxidative stress, caspase-1 and acetylcholinesterase activities, as well as improved the neurite outgrowth."
36646447
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"In the present study, we found that quercetin inhibited the Caspase-1 signaling (Fig. 3A)."
38735388
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"Two antioxidants, NAC and quercetin, suppressed maturation of IL-1β and IL-18, activation of caspase-1 in U937 cells treated with MSU crystals ( Fig. 4 D)."
30166062
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"In addition, quercetin reduced Caspase-1 activity observed in LPS plus nigericin (XREF_FIG)."
28148962
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"Our data indicated that quercetin and aspirin effectively downregulated caspase-1, NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain, and pro-caspase-1 (Fig. 5A–G) on both mRNA and protein levels."
36136273
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"In conclusion, we suggest that CYT and quercetin decrease LPS induced inflammatory cytokine production by inhibiting NF-kappaB and caspase-1 activation."
21108840
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"Among the tested flavones, 7,8-DHF, quercetin, and apigenin reduced Tau aggregation, oxidative stress, and caspase-1 activity as well as improved neurite outgrowth in SH-SY5Y cells expressing ΔK280 Tau RD -DsRed folding reporter."
34975454
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"Subsequently, Caspase-1 inhibition by quercetin and allopurinol prevented kidney IL-1beta and IL-18 release and over-production triggered by hyperuricemia and dyslipidemia in this model."
22701621
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"The current study proved for the first time that quercetin treatment remarkably inhibited hypothalamic NLRP3 and caspase-1 in high fructose fed rats, being consistent with the reduction of hypothalami[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24491314
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"Quercetin significantly inhibited BCRD-induced neuron pyroptosis via downregulation of PYD and card domain containing (ASC), NLR family pyrin domain containing 3 (NLRP3), and caspase-1, and quercetin could reverse BCRD-caused inhibition of neuron viability."
35369029
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"CYT and quercetin also inhibited IL-32 production and caspase-1 activation."
21108840
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"Quercetin blocked Caspase-1/GSDMD signaling (Fig. 4F-G)."
38735388
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"Mechanistically, quercetin blocked the Caspase-1/GSDMD signaling and leakage of AIM2 inflammasomes (Fig. 5F–G)."
38735388