IndraLab

Statements

ROBO1 binds TNF. 2 / 2
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"Slit processing generates an N-terminal fragment (SlitN) that binds to Robo1 and Robo2 receptors and mediates Slit repulsive activity, as well as a C-terminal fragment (SlitC) with an unknown receptor and bioactivity."
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"Its N-terminal fragment (approximately 120kDa), termed Slit2N, can bind to Robo1 to inhibit gp120 and co-receptor-induced cytoskeletal rearrangements associated with LIMK- and cofilin regulated actin polymerization in activated and resting CD4 + T cells."
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