IndraLab

Statements

IKBKE inhibits CYLD. 5 / 6
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"In addition, IKKepsilon has been reported to decrease the activity of CYLD, a deubiquitinating enzyme that negatively regulates IRF3/7 activation, thereby indirectly increasing IRF mediated signaling [XREF_BIBR, XREF_BIBR]."
21994600
sparser
"IKKɛ also phosphorylates and inactivates the tumor suppressor CYLD, preventing CYLD from deubiquitinating specific substrates in the NF-κB signaling pathway."
23333767
sparser
"A similar mechanism is thought to occur in breast carcinogenesis where IKKε phosphorylates and inactivates CYLD ( xref )."
22435550
reach
"IKKepsilon inhibits CYLD activity through phosphorylation, which results in the blockage of the deubiquination of TRAF2 and NF-kB essential modulator (NEMO), positive regulators of the classical NF-kB pathway."
27422962
sparser
"IKKe also phosphorylates and inactivates the tumor suppressor CYLD, preventing CYLD from deubiquitinating specific substrates in the NF-kB signaling pathway."
23333767