IndraLab

Statements

Sorafenib inhibits RIPK1. 5 / 5
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"This demonstrates that Sorafenib inhibits RIPK1 dependent apoptosis and necroptosis equally, but not RIPK1 independent apoptosis."
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"Indeed, there is recent evidence indicating that Sorafenib inhibits RIP1 and RIP3 kinase activity [XREF_BIBR]."
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"43 Sorafenib inhibits both RIPK1 dependent apoptosis and necroptosis, which may explain its protective effect during TNF induced SIRS model."
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"In order to test whether Sorafenib directly inhibits kinase activities of RIPK1 or RIPK3, different in vitro kinase assays were performed (XREF_FIG)."
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"67 As Sorafenib is not specifically inhibiting necroptosis but also RIPK1 kinase dependent apoptosis, one could envisage that during experimental disease models in vivo it may target simultaneously RIPK1 dependent necroptosis and apoptosis."
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