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USP5 inhibits cell growth. 3 / 3
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"The results showed that LSH overexpression efficiently rescued the cell growth and migration arrests induced by the depletion of USP5 (Figure 5L,M, Figure S4I,J)."
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"The forced expression of USP5 isoform 1 in two GBM cell lines inhibited cell growth and migration, implying an important role for USP5 splicing in gliomagenesis."
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"In GBM, USP5 isoform2 was closely associated with the aberrant expression of polypyrimidine tract-binding protein 1 (PTBP1), an RNA splicing factor in GBM, and the forced expression of USP5 isoform1 inhibited cell growth and migration in two GBM cell lines, implying an essential role of individual USP5 isoforms generated by alternative splicing in gliomagenesis ."
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