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USP5 activates Hyperalgesia. 3 / 3
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"A small organic molecule called suramin greatly decreased diabetic neuropathy in ob/ob mice by causing the dissociation of Cav3.2 from USP5, indicating that USP5 promotes hyperalgesia [167]."
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"A report indicated that USP5 promoted hyperalgesia to participate in diabetic neuropathy development in ob / ob mice [ 16 ]."
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"Importantly, the authors showed that prophylactic knockdown of USP5, or prophylactic disruption of the Ca 3.2/USP5 complex, was sufficient to prevent nerve-injury-induced mechanical and thermal hyperalgesia demonstrating the causal implication of the ubiquitinylation machinery in the development of neuropathic pain in this experimental model."
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