IndraLab

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SCN2A decreases the amount of PRNP. 2 / 2
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"We found that incubation of ScN2a cells with a fibril peptide named P9, which comprises an intrinsic sequence of residues 167-184 of mouse PrP (C), significantly reduced the amount of PrP (Sc) in 24 hr."
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"Despite the notable reduction of PrP level produced by GT863 in ScN2a cells, this effect was not observed on N167 cells, instead causing dose-dependent PrP dimer production (Fig. 2a and b)."
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