IndraLab

Statements

OTUD7B increases the amount of TP53. 2 / 2
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"Supporting this possibility, the silencing of OTUD7B expression in HCC cells using two independent shRNAs resulted in the downregulation of p53 protein levels (Figure 2A) whereas the ectopic expression of OTUD7B increased p53 protein levels (Figure 2B)."
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"Interestingly, the regulatory effect of OTUD7B on p53 was not limited to HCC since, for example, the same phenomenon was observed in HeLa cervical cancer cells where silencing OTUD7B similarly decreased p53 protein levels (Figure 2D)."
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