IndraLab

Statements

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"LPS induced TRIF dependent activation of TBK1 and IRF-3 was similarly reduced in TLR4-SNP macrophages (XREF_FIG)."
33216117
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"Taking together these results are consistent with data obtained using microarray technology and functional analyses were LPS triggered TRIF dependent signaling was blocked when DMPO is added to culture medium."
29589052
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"Poly (I : C) or LPS stimulation causes a rapid and dramatic degradation of TRIF to avoid sustained activation of TRIF and expression of type I IFNs and inflammatory cytokines."
28898289
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"TRIF (Toll/IL -1 receptor domain containing adaptor protein inducing IFN-beta), of the MyD88 independent endocytosis pathway, was decreased by LPS (0.72 x, p <.05) and did not respond to nPM (not shown)."
28410596
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"Similar to CD4+ cells, the percent of CD4 negative Vbeta3 T cells producing IFN-gamma was at least 30 percent lower in the TRIF deficient mice treated with LPS (XREF_FIG)."
19380779
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"LPS induced survival was also inhibited by lentiviruses encoding dnMyD88 or a truncated TRIF (Toll and interleukin-1R homologous domain containing adapter protein inducing interferon-beta) molecule, whilst, in contrast, neutrophil survival was enhanced by overexpression of kinase mutated interleukin-1 receptor associated kinase 1 (kmIRAK-1), which activated nuclear factor (NF)-kappaB."
19175800
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"On the other hand, LPS treatment down-regulated IRF3, TBK1 and TRIF in 4F treated MDMs compared to vehicle pre-treatment."
22982462
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"Moreover, deficiency of ATG7, which is an essential E1 ligase for LC3B-II formation, inhibited poly (I : C) - and LPS induced degradation of TRIF (XREF_FIG)."
28898289
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"RT-qPCR revealed that the leptospiral LPS induced much lower TRIF dependent responses than E. coli LPS (XREF_FIG)."
32790743
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"Interestingly, TRIM32 promotes TRIF degradation via the selective instead of the classical autophagic pathway, since deficiency of components of the selective but not classical autophagic pathway inhibited TRIM32 mediated, as well as poly (I : C) - and LPS induced degradation of TRIF."
28898289