IndraLab

Statements

USP28 activates Carcinogenesis. 5 / 5
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eidos
"USP28 contributes to tumorigenesis through modulating the lifespan of oncogenic factors such as c-Myc and DeltaNp63 , and it has been identified as a potential target for anti-cancer drug development ."
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"Taken together, these results suggest that USP28 could potentially modulate tumorigenesis and cancer progression by exerting control over the epigenetic state of cancer cells."
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"USP28 promotes tumorigenesis and has carcinogenic potential through deubiquitination ."
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"In addition, deubiquitinating enzymes USP22 [200], USP28 [201], and OTUD6A [202] stabilize c-Myc and promote tumorigenesis in breast cancer, squamous cell lung carcinoma, and prostate cancer, respectively."
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"Additionally, USP28 and USP10 contribute to tumorigenesis by regulating the DNA damage response and stabilizing p53 under stress conditions [19–21]."
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