IndraLab

Statements

USP37 inhibits vpx. 4 / 4
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"Our study demonstrates that the deubiquitinase USP37 reverses Vpx- and TRIM21-mediated degradation of SAMHD1, thereby inhibiting SIV replication and LINE-1 activity by stabilizing SAMHD1."
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"In conclusion, we have discovered that USP37 extensively inhibited the Vpx-mediated degradation of SAMHD1 across various HIV-2/SIV subtypes."
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"USP37 reverses Vpx-mediated degradation of SAMHD1."
39655951
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"Further analysis showed that USP37 restored the inhibitory effect of Vpx on endogenous SAMHD1 (Fig. 8J)."
39655951