IndraLab

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Modified CTNNB1 decreases the amount of CTNNB1. 12 / 12
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"Furthermore, we find that MITF interferes with beta-catenin directed transcription in SW480 cells (XREF_FIG) and therefore also suppresses the beta-catenin target gene MT1-MMP expression (XREF_FIG)."
21577209
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"Furthermore, in cytoplasmic fraction prepared from the miR-885-5p-overexpressing HCCLM3 cells, the amount of beta-catenin was decreased; therefore, a lesser amount of beta-catenin accumulated in the nucleus of these cells as compared to control cells."
27738331
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"UVB irradiation clearly reduced the expression of wnt3a and beta-catenin, and reduced that of TGF-beta2 and COLI.However, the expression of wnt3a and beta-catenin were significantly increased after ADSC-CM pretreatment after 24h, while that of TGF-beta2 and COLI were upregulated after ADSC-CM pretreatment."
24917925
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"We found that sgRNAs that target beta-catenin or MAP2K1 effectively reduced beta-catenin or MAP2K1 protein levels also inhibited beta-catenin or MAP2K1 mRNA levels (XREF_SUPPLEMENTARY), suggesting that mRNA levels provided a useful metric to assess whether a particular sgRNA affected its target."
27684187
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"More important, beta-catenin expression was down-regulated but phosphorylated beta-catenin expression and phosphorylated GSK-3beta expression was up-regulated upon Nanog overexpression."
25973172
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"We also treated high beta-catenin expressing cell line, BxPC3, with XAV939, beta-catenin inhibitor and siRNA for beta-catenin to inhibit beta-catenin expression."
30360026
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"As protein levels of active beta-catenin decreased in response to 1,25 D 3, decreased mRNA levels of the well established beta-catenin target genes cyclin D1, TCF-7, and MMP-7 were also observed."
26008979
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"It was proposed that high beta-catenin levels blocked NF-kappaB-mediated cell apoptosis and LPS induced NF-kappaB promoted beta-catenin expression and beta-catenin-regulated proliferation in APC mutated or depleted cells where beta-catenin degradation was compromised."
27713747
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"At the same time, the expression of beta-catenin mRNA and protein was dose-dependently downregulated by baicalin in highly invasive breast cancer cell lines, and overexpression of beta-catenin by adenoviruses abolished these beneficial effects of baicalin in regards to the migration and invasion, and EMT of breast cancer cells."
29039569
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"Therefore, since the overall levels of beta-catenin do not change in the absence of ankyrin-G (XREF_FIG and XREF_SUPPLEMENTARY), we hypothesized that reduced levels of E-cadherin and beta-catenin at the plasma membrane following ankyrin-G knockdown might increase the levels of free, non-membrane-bound beta-catenin that would then be available for Wnt signaling."
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"Colonic cell proliferation and beta-catenin expression were analyzed using human colon cancer (COLO 320 DM) cells treated with beta-sitosterol for 24 h. beta-sitosterol administration significantly decreased beta-catenin and PCNA expression in COLO 320 DM cells in vitro."
20525330
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"The rapid decrease in expression of beta -catenin protein after 2 hours of DKK1 treatment (Yamaguchi et al., 2004) might have transiently enhanced the mRNA expression level of beta-catenin, although f[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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