IndraLab

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Mutated BAP1 activates glycolytic process. 4 / 4
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"For example, mesothelioma cells that carry germline BAP1 mutations have upregulated aerobic glycolysis (17), and BAP1 mutant ccRCC tumor samples display elevated glycolysis (22)."
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"These data suggest that BAP1 mutant UM cells have increased aerobic glycolysis compared to BAP1 wild type UM cells."
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"In melanoma, BAP1 mutations promote tumor cell glycolysis, leading to increased lactate production."
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"BAP1 mutations cause a switch from oxidative phosphorylation to aerobic glycolysis [52]."
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