IndraLab

Statements

COPS5 activates SNRNP200. 2 / 2
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reach
"Mutational data initially indicated that the interaction of Prp8 Jab1/MPN with Brr2 was repressive to Brr2 activity (Kuhn et al. 2002), though later biochemical evidence showed that the Jab1/MPN domain in fact activates Brr2 helicase activity (Pena et al. 2007; Maeder et al. 2009) while repressing futile ATPase cycling (Maeder et al. 2009) to make Brr2 a more efficient enzyme."
26968627
reach
"While the entire Jab1 and MPN domain stimulates SNRNP200 helicase activity, XREF_BIBR the C-terminal tail is inserted into the active site of the SNRNP200 helicase and sterically inhibits its activity."
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