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SPP1 increases the amount of USP18. 2 / 2
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"We observed that OPN silencing significantly (p<0.05) decreased USP18 mRNA levels ( Figure 4F ) in fibrotic stiffness gel-attached HepG2.2.15 cells, whereas rOPN treatment did not increase the USP18 mRNA expression in soft gel-attached HepG2.2.15 cells when compared to IFNα-treated group ( Figure 4G )."
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"In addition, we observed that recombinant OPN treatment significantly increased the USP18 protein expression in soft gel attached HepG2.2.15 cells when compared to control cells ( Figure 4H )."
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