
IndraLab
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reach
"By facilitating expression of channel protein HERG, potassium ions may prevent cells from being shunted to procancerous pathways and overbalance the mitochondrial membrane potential through upregulating expression of VDAC1 or breaking the balance of Bcl-2 and Bax ratio and then induced cytochrome c released from mitochondria, caspase activation, and caspase-3/7 ration imbalance, finally resulting in cell apoptosis."