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PKC inhibits KCNK2. 6 / 6
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"In a similar (if less robust) manner, KCNK2 is moderately inhibited by protein kinase C and A ( Fink et al., 1996 ) and activated by arachidonic acid, mechanical stretch, or lowered intracellular pH ([MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11159398
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"PKC and PKA phosphorylation inhibit TREK-1 channels downstream of G s protein-coupled receptor activation in vitro."
33006141
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"On the contrary, TREK-1 channel activity can be inhibited by G -coupled mGluR1/mGluR5 via PKC phosphorylation, G -coupled serotonin (5-HT4R) and β2 noradrenaline receptor (β2-AR) via PKA-dependent phosphorylation [4]."
31728930
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"TREK-1 activation, unlike TRAAK, is reversed by protein kinase A and protein kinase C stimulation [18,19 **,20,24 **,27,30 **]."
11454447
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"In other vascular preparations it was shown that acetylcholine binds to and activates muscarinic receptors in endothelial cells and TREK-1 is inhibited by PKC phosphorylation."
24086441
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"Direct activation of protein kinase C (PKC) reduced the TREK-1 current, whereas PKC inhibition attenuated the AVP mediated reduction of the TREK-1 current, implicating the involvement of PKC."
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