IndraLab

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USP35 activates ferroptosis. 6 / 6
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"These results indicate that USP35 silencing enhances ferroptosis and growth inhibition of ER+ breast cancer cells invoked by ferroptotic stimuli."
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"Our results demonstrated that BRD4 inhibition with (+)-JQ-1 treatment significantly inhibited the ER+ breast tumors enhanced by USP35 overexpression, along with decrease of SLC7A11 protein level, and increase of 4-HNE protein levels (Fig. 7), supporting that BRD4 mediated USP35 inhibition of ferroptosis in ER+ breast tumors.Reported studies have shown SLC7A11 expression can be regulated at translational and post-translational levels ."
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"Together, these results support the notion that USP35 promotes the growth of ER+ breast cancer cells by inhibiting ferroptosis."
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"USP35 promotes the growth of ER positive breast cancer by inhibiting ferroptosis via BRD4-SLC7A11 axis."
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"Additionally, USP35 targeted ferroportin and induced ferroptosis in NSCLC (87)."
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"USP35 promotes the growth of ER+ breast cancer cells by inhibiting ferroptosis."
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