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Mutated TP53 bound to HSP90 activates TP53. 1 / 1

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"Thus, we speculated that the R280 mutant of p53 or abnormal interaction with Hsp90 might assist in the misfolding of p53 in NPC and accelerate p53 accumulation in the cytoplasm, ultimately resulting in the loss of p53 function in NPC.In this study, we first found that aggregated p53 amyloid formation was widespread in NPC."

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IndraLab

Statements

Mutated TP53 bound to HSP90 activates TP53. 1 / 1

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