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USP4 leads to the deubiquitination of IRF8. 2 / 2
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"USP4 deficiency promotes K48-linked polyubiquitination of IRF8 and upregulates the gene expression levels of type 2 inflammatory cytokines in Treg cells, such as IL-4, IL-5 and IL-13."
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"In the present study, we demonstrate that <span class="match term0">ubiquitin-specific protease (USP)4</span> physically interacted with interferon regulatory factor 8 (<span class="match term1">IRF8</span>) function via a K48-linked deubiquitinase, which stabilized <span class="match term1">IRF8</span> protein levels in Treg cells."
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