IndraLab

Statements

KCNH2 activates dTDP. 7 / 7
| 7
reach
"Despite being of such importance for drug discovery, the relevance and impact of hERG data are sometimes misinterpreted, as there are drugs that block the hERG coded ion channel but do not cause TdP, and drugs that cause TdP but do not block the hERG channel."
22111613
reach
"In the second step, the role of non hERG channels to modulate TdP risk are considered by constructing classifiers based on direct or derived features at critical hERG block concentrations that generates EADs in the computational cardiac cell models."
29184497
reach
"However, not all drugs that block hERG cause TdP."
29456831
reach
"XREF_BIBR Loss-of-function mutations in hERG cause a reduction in the I Kr current of up to 97%, XREF_BIBR which causes QT prolongation, and usually increases risk of TdP."
29456831
reach
"Drugs that cause TdP block hERG cardiac potassium channels, but not all drugs that block hERG cause TdP XREF_BIBR."
33605379
reach
"To date, in patients with LQT2, the majority of mutations in hERG increase the transmural dispersion of repolarization and eventually induce prolongation of the QT interval, a notched T wave, re-entry and TdP."
26847485
reach
"Sparfloxacin is a fluoroquinone antibiotic and HERG channel antagonist that is known to cause QT prolongation, Tdp and ventricular fibrillation [XREF_BIBR, XREF_BIBR]."
21453966