IndraLab

Statements


Glucose decreases the amount of CYLD. 5 / 5
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"In the present study, we found that high glucose dose- and time-dependently downregulated the protein and mRNA expressions of CYLD in GMCs (SV40 MES 13 and HBZY-1) and increased the expression levels of p-IkappaBalpha, NF-kappaBp65, and p-NF-kappaBp65, and furthermore induced the release of MCP-1, IL-6, and IL-8."

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"Our data showed that high glucose significantly inhibited the protein and mRNA expression of CYLD in a dose- and time dependent manner (both p < 0.05)."

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"High Glucose Inhibits the Expression of CYLD in GMCs."

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"In conclusion, the present study found that high glucose significantly inhibited the expression of CYLD and activated NF-kappaB inflammatory signaling in a dose- and time dependent manner."

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"These data suggest that high glucose inhibited CYLD expression in GMCs (SV40 MES 13 and HBZY-1) in a time- and dose dependent manner."