IndraLab

Statements

CUL4B inhibits COPS5. 7 / 7
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"Here, accumulation of Jab1 caused by CUL4B knockdown leads to a considerable increase in BMP signaling, which may play a mechanistic role in this process."
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"Consistent with the known function of Jab1, the current findings show that the accumulation of Jab1 caused by CUL4B knockdown also leads to a considerable upregulation in BMP signaling.XLID occurrence[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CUL4B E3 ligase was shown to mediate the proteasomal degradation of Jab1."
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"Next, cells treated with siRNAs specific for CUL4B, CUL4B + Jab1 (to offset the effect of Jab1 accumulation caused by silencing of CUL4B), or with control siRNAs."
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"Omission of the ubiquitin, E1 and E2, or CUL4B immunocomplexes diminished the Jab1 polyubiquitin ladder."
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"Notably, CUL4B silencing did not cause a change in abundance in the three other homologous mammalian CSN proteins (CSN2, CSN4, and CSN6), indicating the specificity of CUL4B targeted Jab1 degradation."
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"Here, the experimental evidences showed that CUL4B, but not CUL4A, mediates the proteasomal degradation of Jab1."
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