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INS activates KCNMA1. 12 / 12
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"In contrast, insulin activates K ATP and BK channel by stimulating MAPK."

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"We showed that insulin markedly enhanced the Slo1 subunit content in the membrane fraction and concomitantly decreased the Slo1 content in the cytosolic fraction."

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"However, insulin acts to stimulate BK channel activity and expression, which is blocked by the presence of high glucose."

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"In addition, Eun Young Kim 's group investigated insulin modulation of BK channel activity associated with activation of Erk and MAPK and PI3K and Akt signaling pathways in podocytes."

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"In parallel studies, insulin, applied via the pipette or bath, also activated hSlo channels expressed in HEK293 cells."

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"Likewise, BK channel activation by insulin is blocked by actin filament stabilization xref ."

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"Fig. 8 shows that insulin markedly enhanced the Slo1 subunit content in the membrane fraction, by about 132% (P < 0.05)."

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"Here we demonstrate that in hippocampal neurons, BK channel activation by insulin is blocked by actin filament stabilization, suggesting that this process is dependent on the actin cytoskeleton."

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"Furthermore, insulin activation of this pathway enhances BK channel activity by shifting the Ca (2+)-sensitivity such that BK channels are active at more hyperpolarized membrane potentials."

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"Likewise, BK channel activation by insulin is blocked by actin filament stabilization XREF_BIBR."

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"Here we demonstrate that in hippocampal neurons, BK channel activation by insulin is blocked by actin filament stabilization, suggesting that this process is dependent on the actin cytoskeleton."

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"These data are consistent with BK channel activation by insulin involving MAPK-dependent alterations in actin dynamics."