IndraLab

Statements

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"CYLD inhibits cervical cancer cell growth, survival, invasion, and migration."
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"Together, these findings suggest that CYLD restricts infiltration of inflammatory cells and invasion enhanced by increased hypoxia after anti-VEGF therapy in GBM."
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"Furthermore, we found that loss of CYLD promoted HeLa cells invasion and migration (Figure 4D)."
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"We found in Supplementary Figure 6A–C that CYLD over-expression suppressed cell proliferation and cell migration and invasion, whereas promoted apoptosis in SiHa cells."
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"For example, inhibition of CYLD expression enhanced human malignant melanoma growth and invasion [XREF_BIBR]."
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"Studies found that miR-362-5p reduces the expression of tumor suppressor protein CYLD, which leads to activate the NF-kB pathway to promote the proliferation, migration, and invasion of hepatocellular carcinoma cells and human breast cancer cells (Ni et al., 2015; Ni et al., 2016)."
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"Loss of CYLD stimulates cellular proliferation , migration , and invasion by triggering BCL-3 nucleus translocation and activation of cyclin D1 and N-cadherin [ 99 ] ."
| PMC
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"Furthermore , we found that CYLD deficiency promoted cervical cancer cell proliferation , colony formation , cell migration and invasion , and inhibited apoptosis instead , whereas it is just opposite with CYLD over-expression ."
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"Furthermore, CYLD overexpression inhibited SMAD7 mediated cell invasion, while CYLD depletion increased SMAD7 mediated cell invasion in OSCC cells."
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"Rescue of CYLD expression in melanoma cells reduced proliferation and invasion in vitro and tumor growth and metastasis in vivo."
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"Treatment with sorafenib, EAC and sorafenib/EAC inhibited cell invasion by 57.0%, 67.5% and 86.4%, respectively (Fig.  xref )."
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"Compared with the control group, miR-181 silencing or CYLD overexpression significantly attenuated cell proliferation, invasion and migration, and notably increased the proportion of apoptotic cells."
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"These clinical findings support a link between the known tumor promoter Snail1 and its transcriptional target CYLD, indicating an important role for Snail1 to suppress CYLD during progression of melanoma and for CYLD to suppress melanoma cell proliferation and invasion."
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"XREF_BIBR Additionally, Sanches et al XREF_BIBR showed that CYLD suppresses cell migration and invasion in cervical cancer, and Suenaga et al XREF_BIBR reported that CYLD downregulates induction of cisplatin resistance in oral squamous cell carcinoma."
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"Loss of CYLD promotes cell invasion via ALK5 stabilization in oral squamous cell carcinoma."
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"The loss of CYLD in HNSCC can also increase the invasiveness of HNSCC by promoting transforming growth factor beta receptor 1 (ALK5) to stabilize NF-κB. 9."
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"Loss of CYLD stimulates cellular proliferation, migration, and invasion by triggering BCL-3 nucleus translocation and activation of cyclin D1 and N-cadherin [XREF_BIBR]."
| PMC