IndraLab

Statements

USP9X activates Death. 3 / 3
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"A novel mechanism of action was found in which the peptide reduces expression of the deubiquitinating enzyme Usp9X, which in turn leads to depletion of Mcl-1 and Bcl-2 and to consequent apoptotic death."
27126996
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"Finally, the Usp9X pharmacological inhibitor WP1130 significantly reduced human MPNST growth and induced tumor cell death in an in vivo xenograft model."
30478285
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"It can display both pro- and anti-cell death functions, mediated by the ability of USP9X to deubiquitylate the critical components of the apoptotic signalling networks."
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