IndraLab

Statements

OTUD7B activates Hypertrophy. 5 / 5
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"Additional molecular experiments showed that OTUD7B impedes KLF4 degradation by inhibiting lysine residue at 48 site-linked ubiquitination and suppressing myocardial hypertrophy by activating the serine/threonine kinase pathway."
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"OTUD7B alleviates PE-induced cardiomyocyte hypertrophy in vitro."
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"These findings indicate that OTUD7B effectively mitigates PE-induced pathological myocardial hypertrophy (Fig. 3E, F, G, H)."
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"Cardiac-specific OTUD7B deficiency exacerbated, while OTUD7B overexpression mitigated, pressure overload-induced hypertrophy and cardiac dysfunction both in vivo and in vitro."
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"OTUD7B mitigates dysregulation of fatty acid metabolism in PE-induced cardiac hypertrophy."
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