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Statements

Sodium(1+) inhibits KCNH2. 5 / 9
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"Intracellular Sodium Inhibits HERG Current in a Manner Consistent with Voltage dependent Block and Independent of Extracellular Sodium."
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"The predictable outward tail currents recorded from WT channels in those conditions (data not shown) were small due to the fact that extracellular sodium potently inhibits hERG channels when extracell[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Due to the possibility that these small organic counterions contributed to the inhibition produced by pergolide and sumanirole, sodium methanesulfonate and maleic acid were tested for the ability to i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Sodium channel blockers that shorten the APD, even when devoid of hERG blocking properties, can yield torsade de pointes."
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"Thus, the positive control demonstrated hERG inhibition and confirmed assay sensitivity and accuracy.Imetelstat sodium at 125 μg/mL (n = 5) produced hERG current inhibition of 5.9% ± 3.6%, which was similar to vehicle control (Table 1)."
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