IndraLab

Statements

PABP activates PAN2. 3 / 3
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"PABP regulates deadenylation of mRNPs by binding Pan3 and stimulating Pan2 nuclease activity and interacting with GW182 [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR] through a C-terminal motif that is removed by both viral proteinases."
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"To initiate deadenylation, the two PAN3 subunits recognize two poly(A)-bound PABP molecules allowing the RNase active site of PAN2 to remove the 3′ terminal A residues of mRNA poly(A) tail [ 6 , 7 ]."
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"PAN2 is activated by PABP in vitro XREF_BIBR."
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