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USP37 increases the amount of USP37. 3 / 3
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"Besides, the overexpression of CI USP37 significantly increased the ubiquitination level of USP37 (XREF_FIG N)."
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"After a correlation of OS and DFS was seen with the expression of USP37, we modulated the expression of USP37 by overexpression and depletion of USP37 to identify its molecular targets in osteosarcoma especially pertaining to replication stress."
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"The results showed reduced survival of U2OS cells in colony formation assays after USP37 inhibition and exposure to HU-mediated replication stress, while overexpression of USP37 led to enhanced survival in response to HU (Fig. 4A), suggesting that USP37 plays a crucial role in aiding the survival of osteosarcoma cells under replication stress.Exposure to replication stress has been shown to affect the spatial localization and levels of USP37 and its associated interacting partners."
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