IndraLab

Statements

KCNMA1-N402C activates IL1B. 4 / 4
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"Increased IL-1beta Production by SLO N402C."
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"To demonstrate that both SLO and SLO N402C were triggering inflammasome dependent IL-1beta secretion, we treated LPS primed Casp1 -/- BMDM with SLO or SLO N402C and measured IL-1beta secretion by ELISA."
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"These data indicate that a similar hemolytic activity of SLO N402C promotes greater IL-1beta secretion than wild type SLO."
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"However, a partially active mutant (SLO N402C) that was less toxic to macrophages than wild-type SLO, even at concentrations that directly lysed an equivalent number of red blood cells, enhanced IL-1beta production but did not alter pyroptosis."
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