IndraLab

Statements

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"Downregulation of USP47 inhibited the proliferation of imatinib-sensitive or drug-resistant CML cells."
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"Here, we demonstrate that miR-101-3p regulates the RPL11-MDM2-p53 pathway by targeting ubiquitin-specific peptidase 47 (USP47), consequently inhibiting cancer cell proliferation."
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"Moreover, USP47 knockdown could repress CRC cell proliferation, which could be rescued by YAP overexpression (Pan et al., 2020)."
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"The deficiency of USP47 impaired the transcriptional activity of SATB1 target genes and inhibited cell proliferation, migration, and tumorigenesis in a mouse model of colon cancer."
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"Of note, USP47 KO did not affect cell proliferation, while USP7/USP47 DKO led to reduced cell proliferation (Supplemental Fig. S3A,B)."
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