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Pyraclofos activates SCN10A. 4 / 4
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"G(V) relationship indicated that BmK I shifted voltage-dependent activation of Nav1.8 in a hyperpolarizing direction (Fig. 4A)."
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"Intheproton-dependenteffect inthedihydropyridinereceptor(41,42),thezinceffectinthe cardiac batrachotoxin-modified voltage-activated sodium channel(39,43),andthebovinepancreatictrypsininhibitor effect [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In contrast, the Nav1.9 subunit (also known as NaN or SNS2) generates a low voltage–activated (LVA) channel current with very slow activation and inactivation rates and larger single channel conductance (Herzog et al., 2001; Coste et al., 2004)."
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"Voltage protocol used to elicit both Nav1.9 (first depolarization to −55 mV) and Nav1.8 currents (second depolarization to 0 mV) in a rat DRG neuron is shown below the trace."
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