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Pyraclofos activates SCN10A. 7 / 7
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"In contrast, the Nav1.9 subunit (also known as NaN or SNS2) generates a low voltage–activated (LVA) channel current with very slow activation and inactivation rates and larger single channel conductance (Herzog et al., 2001; Coste et al., 2004)."
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"Our results showed that the gate voltage increases the carriers in the SnS layer."
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"Intheproton-dependenteffect inthedihydropyridinereceptor(41,42),thezinceffectinthe cardiac batrachotoxin-modified voltage-activated sodium channel(39,43),andthebovinepancreatictrypsininhibitor effect [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"G(V) relationship indicated that BmK I shifted voltage-dependent activation of Nav1.8 in a hyperpolarizing direction (Fig. 4A)."
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"Voltage protocol used to elicit both Nav1.9 (first depolarization to −55 mV) and Nav1.8 currents (second depolarization to 0 mV) in a rat DRG neuron is shown below the trace."
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"For example, it has been reported that the Nav1.8 current density was markedly decreased in injured dorsal root ganglion (DRG) neurons following CCI, while the voltage-dependent activation of the Nav1.8 channel in these neurons was shifted to depolarized potentials by 5.3 mV and inactivation shifted to hyperpolarized potentials by 10 mV (Li et al., 2015)."
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"Moreover, the few genes known to encode ion channels, such as Scn10a encoding the voltage activated sodium channel Nav1.8 (Han et al., 2016), are well characterized and unlikely to encode MS channels."
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